A newly defined interleukin-1?
نویسندگان
چکیده
منابع مشابه
Differential interleukin-1 elaboration by density-defined human monocyte subpopulations.
Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their su...
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The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a variety of genes and the synthesis of several proteins that, in turn, induce acute and chronic inflammatory changes. IL-1 is also the prototypic "alarm" cytokine in that it brings about increases in a variety o...
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ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/379591a0